Sorted B cell transcriptomes point towards actively regulated B cell responses during ongoing chronic hepatitis B infections

The natural course of chronic hepatitis B virus (HBV) infections follows distinct clinical disease phases, characterized by fluctuating levels serum HBV DNA and ALT. immune cells their features that govern these transitions remain unknown. In the current study, we performed RNA sequencing on purified from blood (n = 42) liver 10) healthy controls patients. We found gene expression profiles between patients, as evidenced 190 differentially expressed genes (DEG), but also phenotypes a infection (17–110 DEG each phase). Numerous pathways, including cell receptor pathway were upregulated in when compared to peripheral cells. Further investigation detected suggested an activation during HBeAg seroconversion active regulation signalling liver.